Welcome to the Evelyn F. McKnight Brain Institute at the University of Miami. We are grateful for the support of the McKnight Brain Research Foundation that established our Institute to investigate and treat age-related cognitive decline. Our basic and clinical research cores support multi-disciplinary research across scientific disciplines, and our educational programs foster the growth of scientists and clinicians at all levels of training and of the community at large. Through our collaborative and translational programs across McKnight Brain Institutes at the University of Alabama, the University of Arizona, and the University of Florida we hope to pioneer approaches that accelerate treatments and practical interventions to address the needs of our aging population.