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Antoni Barrientos, PhD

barrientos-195x260Associate Professor of Neurology
Associate Professor of Biochemistry & Molecular Biology
Leonard M. Miller School of Medicine
Evelyn F. McKnight Brain Institute
Phone: 305-243-8683
Email: abarrientos@med.miami.edu
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Dr. Barrientos is interested in the basic processes underlying the biogenesis of the mitochondrial respiratory chain (MRC) and how they bear on human neuromuscular and neurodegenerative disorders and during the aging process. We use yeast and mammalian cell culture models for our research
Three of the research lines in the lab involve:
1- We intend to delineate the assembly process of the enzymes composing the MRC, with special emphasis in cytochrome c oxidase (COX). COX deficiency is the most frequent cause of mitochondrial neuromyopathies in humans and has been shown to decline with age.
2- We are interested in the creation of yeast and neuronal models of age-related human neurodegenerative disorders (including Huntington’s disease and Parkinson’s disease). This will help us study the alterations in mitochondrial physiology that could be essential for the pathogenic mechanism of such disorders.
3- We have created novel yeast models of chronological aging that are being used to explore the role of mitochondrial function in the aging-disease relationship. The results obtained are being validated in mammalian neuronal aging models.

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Susan Halloran Blanton, PhD

blanton-195x260Executive Director, Hussman Institute for Human Genomics
Associate Professor of Human Genetics and Neurology
Dr. John T. Macdonald Department of Human Genetics
Associate Director of Communications and Compliance
Hussman Institute for Human Genomics
PO Box 019132 (M-860)
Biomedical Research Building, Room 406
University of Miami Miller School of Medicine
Miami, FL 33101
Phone: 305-243-2321
Fax: 305-243-2523
Email: SBlanton@med.miami.edu
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Dr. Blanton received her PhD in Human Genetics from Virginia Commonwealth University/Medical College of Virginia. She obtained post-doctoral training in Biostatistics (University of Pittsburgh) and Population Oncology (Fox Chase Cancer Center). Her primary research has focused on the mapping of genes for Mendelian and complex diseases; she has been instrumental in studies identifying over twenty genes/loci for Mendelian disorders. Stroke and the underlying genetics of its risk factors, deafness, retinal diseases, skeletal dysplasias, cleft lip/palate, and clubfoot are among the diseases which she currently studies. She collaborates with Drs. Sacco, Wright and Rundek to identify genetic factors influencing white matter and cognition and their relation to ageing. In addition, she has been involved in developing and implementing genetic education materials for Federal and appellate level judges and science writers in an ELSI sponsored project. Dr. Blanton is the Executive Director of the Hussman Institute for Human Genomics as well as the Associate Director of Communications and Compliance. She is an Associate Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics.

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Elizabeth Crocco, MD

crocco-195x260Chief, Division of Geriatric Psychiatry
Department of Psychiatry and Behavioral Sciences
Miller School of Medicine/University of Miami
Geriatric Psychiatry Training Director
Jackson Memorial Hospital
1695 NW 9th Avenue
Suite 3204A
Miami, FL 33136
Phone: 305-355-9065
Fax: 305-355-9076
Email: ecrocco@med.miami.edu

Dr. Elizabeth Crocco received her MD from Robert Wood Johnson Medical School/Rutgers University in Piscataway, New Jersey. She then completed her residency training in general psychiatry at The Mount Sinai Medical Center in New York. She specializes in geriatric psychiatry, and completed her fellowship at University of Miami/Jackson Memorial Hospital. Dr. Crocco is currently the Chief of Geriatric Psychiatry in the Department of Psychiatry and Behavioral Sciences at the Miller School of Medicine. As the Medical Director of the University of Miami Memory Disorder Clinic, within the University of Miami’s Center on Aging she oversees the coordination of clinical services at the MDC. As a clinical scientist she also participates in research on caregiving and the development of measures to diagnosis MCI and PRE-MCI. She also serves as the geriatric psychiatry training director at Jackson Memorial Hospital and facilitates the primary training and supervision of all geriatric psychiatry fellows, psychiatry residents, medical students and other physicians/health care professionals.

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Chuanhui Dong, PhD

dong-195x260Biostatistician
Evelyn F. McKnight Brain Institute
Research Associate Professor
Department of Neurology
University of Miami, Miller School of Medicine
1120 NW 14th Street, Suite 1346
Miami, FL 33136
Phone: 305-243-9274
Email: cdong@med.miami.edu

Dr. Dong is Research Associate Professor of Neurology and Biostatistician for the McKnight Brain Institute. Dr. Dong’s research focus is on the independent and interactive effects of social-demographic, environmental, behavioral, metabolic and genetic factors on the risk of complex diseases such as metabolic disorders, depression, cognition, drug response to clinical treatment, subclinical and clinical cardiovascular diseases. He is a member of the American Heart Association, the American Statistical Association, the International Genetic Epidemiology Society and the American Association of Human Genetics.

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Hannah Gardener, ScD

gardener-195x260Assistant Scientist
Department of Neurology
University of Miami
Miller School of Medicine
1120 NW 14th St
Miami, FL 33136
Phone: 305-243-9283
Email: hgardener@med.miami.edu

Hannah Gardener, ScD, Assistant Scientist in the Department of Neurology at the University of Miami, is an epidemiologist with a particular interest in neuroepidemiology and the epidemiology of aging. She received her doctorate in Epidemiology in 2007 from the Harvard School of Public Health. She has been conducting research on risk factors for clinical and subclinical vascular outcomes in the Northern Manhattan Study for over seven years. She is particularly interested in dietary behavior and other modifiable vascular risk factors in relation to vascular events, carotid disease, and age-related changes in brain structure and cognitive decline.

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Teshamae S Monteith, MD, FAHS

monteith-195x260Chief, Headache Division
Assistant Professor Clinical Neurology
Department of Neurology
University of Miami, Miller School of Medicine
1120 NW 14th Street, Suite 1347
Miami, FL 33136
Phone: 305-243-1029
Email: tmonteith@miami.edu

Dr. Monteith is an Assistant Professor of Clinical Neurology. She is Chief of the Division of Headache in the Department of Neurology. She also has clinics at the Advanced Institute for Pain Management. Dr. Monteith’s research focus is on migraine and chronic disease states including chronic migraine and concussion. Her research focuses on neurometabolite distributions of chronic migraine and associations with indicators of clinical severity, including psychosocial impact.

She was awarded a National Institutes of Health (NINDS) supplement award to promote diversity in health-related research to study migraine and vascular risk factors, and complications such as silent brain infarcts, white matter lesions, and stroke. She is also the site PI for clinical trial aimed to investigate the use of CGRP antibodies for the treatment of both episodic and chronic cluster headache. She is a member of the American Headache Society Association, the American Academy of Neurology, and the International Headache Society. She is a board member of the Florida Society of Neurology.

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Carlos T. Moraes, PhD

moraes-195x260Esther Lichtenstein Professor in Neurology
University of Miami, Miller School of Medicine
Dept. of Neurology and Cell Biology
1420 NW 9th Avenue, Rm.229
Miami, FL 33136
Phone: 305-243-5858
Email: cmoraes@med.miami.edu
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Carlos T. Moraes, PhD is a Professor in the Department of Neurology with a secondary appointment in Cell Biology at the University of Miami, Leonard M. Miller School of Medicine. During his PhD at Columbia University he and other colleagues in the group identified large mitochondrial DNA deletions in patients with ocular myopathies. These initial observations were followed by the identification of several novel mutations in the mitochondrial genome in patients with different clinical phenotypes. Following a short postdoctoral period still at Columbia University he relocated to Miami in 1993 to start an independent research group on mitochondrial genetics. At the University of Miami he continued his work on mitochondrial diseases, developing genetic approaches to treat mitochondrial disorders and expanded to study nuclear mitochondrial interactions and the role of mitochondria in aging and neurodegenerative diseases, including Alzheimer’s. Dr. Moraes has and continues to serve on several NIH panels including the Muscular Dystrophy Association grant review panels.

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Miguel A. Perez-Pinzon, PhD

perez-195x260Professor of Neurology & Neuroscience
Vice-Chair for Basic Science (Neurology)
Director, Cerebral Vascular Disease Research Laboratories
Dept. of Neurology, D4-5
University of Miami Miller School of Medicine
P.O. Box 016960
Miami, FL 33101
Phone: 305-243-7698
Email: perezpinzon@miami.edu
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A major emphasis in our group is directed towards understanding the mechanisms of neuroprotection by ischemic preconditioning (IPC) against cerebral ischemia (as elicited by a stroke or cardiac arrest). We have demonstrated in brain that IPC is mediated by two key signaling pathways. One of these pathways is a protein kinase C isozyme epsilon. Another signaling pathway involves the NAD+-dependent class III histone deacetylase SIRT1. Our laboratory is fully engaged in defining how these signaling pathways protect neurons against cell death. We are currently studying how these pathways alter synaptic plasticity and ameliorate mitochondrial function.

Another area of emphasis in our group is defining mechanisms by which some signaling pathways alter synaptic function following cardiac arrest. Cardiopulmonary arrest remains one of the leading causes of death and disability in the U.S.A. The chances of survival following cardiac arrest are poor, despite fast emergency responses and better techniques of defibrillation. Cardiac arrest with its consequent disruption of blood flow sets in motion a cascade of cellular derangements that result in brain damage.

A third area of emphasis in our group is the definition of the mechanisms of mitochondrial dysfunction following cerebral ischemia. It has been postulated that delayed cell death after brain ischemia may result from two different mechanisms: apoptosis and/or necrosis. In both pathways however, mitochondrial dysfunction appears to play a pivotal role. We are currently investigating the signaling pathways that lead to mitochondrial dysfunction following cerebral ischemia.

Milena Pinto, PhD

pinto-195x260Research Assistant Professor
Department of Neurology
University of Miami, Miller School of Medicine
1420 NW 9th Avenue, Room 231
Miami, FL 33136
Phone: 305-243-4232
Email: mpinto@med.miami.edu

Milena Pinto, PhD is a Research Assistant Professor in the Department of Neurology at the University of Miami, Leonard M. Miller School of Medicine.

She has more than ten years of research experience on neurodegenerative disorders, in particular on Parkinson’s and Alzheimer’s disease. She obtained her PhD in Functional genomics and Neurobiology in Italy, where she extensively worked on drug-induced and genetically modified animal models of Parkinson’s disease as well as on cellular models of dopaminergic neurons. More recently, during her postdoctoral training, she has been involved in understanding the possible neuronal-specific role of mitochondrial dysfunctions and mitochondrial DNA deletions and depletion in different mouse models of aging and neurodegenerative diseases.

 

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Alberto Ramos, MD, MSPH, FAASM

ramos-195x260Assistant Professor of Clinical Neurology
Co-Director of the Sleep Disorders Program
University of Miami, Miller School of Medicine
1120 NW 14th Street, Suite 1350 (C215)
Miami, FL 33136
Phone: 305-243-8393
Email: aramos@med.miami.edu

Dr. Ramos’ research focus is on sleep and cerebrovascular disease. Dr. Ramos was the recipient of a Research Supplement in Health Related Research – an NIH/NINDS funded supplement grant to the ongoing Northern Manhattan Study, to study the relationship between sleep and risk factors for stroke. Dr. Ramos is the site Principal Investigator for the Sleep Patterns as a Risk Factor for Disease in the Hispanic Community Health Study – Field Center at the University of Miami which is an n NHLBI funded ancillary study to the Hispanic Community Health Study to evaluate sleep patterns and cardiovascular risk in Hispanics. Dr. Ramos is also the recipient of Mentored Translational Research Scholars Program (K12) from the CTSI at the Miller School of Medicine. The K12 research study evaluates cerebral hemodynamics and impaired cerebral vasomotor reactivity in obstructive sleep apnea utilizing the Hispanic Community Health Study. He is a member of the American Academy of Sleep Medicine and the Sleep Research Society.